Treatment-Emergent Psychosis With Aripiprazole

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Sir: Aripiprazole, the latest atypical antipsychotic to receive approval by the U.S. Food and Drug Administration, is unique in its action as a partial agonist at dopamine receptors.1 Partial agonists can function as net agonists or net antagonists, depending on the amount of naturally occurring full agonist neurotransmitter that is present. Aripiprazole has antagonist activity at dopamine-2 (D2) receptors in a hyperdopaminergic environment and agonist activity in a hypodopaminergic environment.​

J Clin Psychiatry 2005;66(10):1339[letter]