Initial Evidence of the Beneficial Effects of Glutamate-Modulating Agents in the Treatment of Self-Injurious Behavior Associated With Borderline Personality Disorder

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Sir: Self-injurious behavior (SIB) in patients with borderline personality disorder (BPD), especially cutting, represents a serious and often intractable clinical problem.1 There are few validated pharmacologic strategies for managing SIB.1–3 We describe our initial experience using glutamate-modulating agents in 2 patients with BPD and prominent SIBs.​

J Clin Psychiatry 2005;66(11):1492-1493