Reexamining Paroxetine and Cognitive-Behavioral Therapy in Postpartum Depression and Anxiety

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Sir: The recent (September 2004) study by Misri et al.1 evaluating the use of paroxetine and cognitive-behavioral therapy (CBT) to treat postpartum depression and anxiety is timely and informative; however, I have several concerns. The results of the study are not generalizable to the majority of women with postpartum depression and anxiety. At best, the sample is representative only of the very small subset of women with severe comorbid anxiety and depression who are diagnosed by their primary care physician and referred for specialty care.​

J Clin Psychiatry 2005;66(11):1494-1495