ASCP Corner: Real-Life Dosing With Second-Generation Antipsychotics
J Clin Psychiatry 2005;66(12):1610-1611
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Because this piece has no abstract, we have provided for your benefit the first 3 sentences of the full text.
This is the first of 2 articles addressing
methodological issues regarding real-life
dosing and switching strategies when
treating patients with second-generation
When faced with nonresponse to an adequate
duration of antipsychotic treatment
at maximum recommended doses, clinicians
have 4 basic options to improve
symptomatic and/or functional response:
(1) wait for the occurrence of a potentially
delayed response; (2) augment with another
medication (of the same or a different
class); (3) switch to another medication
(of the same or a different class); or
(4) increase the dose beyond the upper
dose range used in U.S. Food and Drug
Administration (FDA) approval trials. If
sufficient data were available, a fifth option
could be to check for the presence of
therapeutic antipsychotic drug levels.