Omega-3 Fatty Acids Are More Beneficial in the Depressive Phase Than in the Manic Phase in Patients With Bipolar I Disorder."

View This PDF

NB: This article is only available as a PDF.

Because this piece has no abstract, we have provided for your benefit the first 3 sentences of the full text.

Sir: We read with interest the recent (June 2005) report by Osher et al.1 that described the potential effectiveness of omega- 3 polyunsaturated fatty acids (PUFAs) in the treatment of bipolar depression.1 In 1999, Stoll et al.2 found that adjunctive treatment with omega-3 PUFAs had a mood-stabilizing effect in patients with bipolar disorder in their 4-month doubleblind, placebo-controlled study. In our reexamination of the data reported by Stoll et al., we3 found that all “non-completed” cases (3 of 14 cases) in the omega-3 group developed a manic episode, whereas the depressive symptoms in all but 1 of the non-completed cases (10 of 16 cases), in the placebo group worsened.​

J Clin Psychiatry 2005;66(12):1613-1614