Clonidine-Induced Gynecomastia and Hyperprolactinemia in a 6-Year-Old Child

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Sir: Clonidine, an α2-adrenergic receptor agonist, has been used in children with attention-deficit/hyperactivity disorder (ADHD).1 Although there are several reports of gynecomastia and hyperprolactinemia induced by antihypertensive agents,2 to my knowledge there is no report of gynecomastia associated with clonidine treatment.

Case report. A 6-year-old boy presented in 2004 with a 1-year history of hyperactivity, inattentiveness, irritability, and easy distractibility. He fulfilled DSM-IV criteria for ADHD, for which treatment with methylphenidate, 20 mg/day was started, which led to no improvement. After 3 months, methylphenidate was replaced by clonidine.​​

J Clin Psychiatry 2005;66(12):1616-1616