Benzodiazepines in Clinical Practice: Consideration of Their Long-Term Use and Alternative Agents
J Clin Psychiatry 2005;66(suppl 2):21-27
© Copyright 2015 Physicians Postgraduate Press, Inc.
Access to this article is available to valid users
Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send email
Register: If you do not have one already, register for a free account.
Despite increasing focus on the use of antidepressants and other agents for the treatment of anxiety,
benzodiazepines have remained a mainstay of anxiolytic pharmacotherapy due to their robust efficacy,
rapid onset of therapeutic effect, and generally favorable side effect profile. In this article, we
examine issues related to the long-term use of benzodiazepines, including concerns about the development
of therapeutic tolerance, dose escalation, and adverse cognitive effects. We also consider currently
available alternatives to benzodiazepines and novel mechanisms of action that may prove fruitful
in the development of future generations of anxiolytics.