The Implications of Medical and Psychiatric Comorbidity With Panic Disorder
J Clin Psychiatry 2005;66(suppl 4):8-15
© Copyright 2017 Physicians Postgraduate Press, Inc.
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The frequent presentation of patients with panic disorder in medical settings may, in part, be explained
by the physical symptoms inherent in panic disorder. However, a number of medical disorders
have symptoms that overlap with panic disorder symptoms, and elevated panic disorder prevalence is
comorbid with a number of medical illnesses, including respiratory disorders, vestibular dysfunction,
and hyperthyroidism and hypothyroidism. The presence of medical comorbidity complicates the identification,
presentation, and treatment of panic disorder. In addition, comorbid mood disorders occur
commonly and result in greater severity, poorer quality of life, and greater impairment. Recent work
suggests that panic disorder occurs more commonly with bipolar disorder than major depressive disorder,
resulting in substantial impairment, as well as poorer response to treatment. The implications of
mood disorder and its medical comorbidity for the identification and treatment of panic disorder are