The article you requested is
Comorbid Anxiety and Depression.
J Clin Psychiatry 2005;66(suppl 8):22-29
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Anxiety and depressive disorders often occur as comorbid illnesses and share many common
symptoms. Risk factors for these disorders most likely include interactions of environmental and genetic
factors. The presence of comorbid anxiety and depression adversely affects clinical and treatment
outcomes. Selective serotonin reuptake inhibitors are usually considered first-line treatment for
patients with these disorders, although alternative antidepressants or additional therapies are often
necessary. Studies suggest that benzodiazepines, anticonvulsants, and atypical antipsychotics may be
effective as augmentation therapy to optimize outcome, with buspirone and beta-blockers useful
in some patients as well. Cognitive-behavioral therapy is also an effective therapeutic alternative for