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3-Acetyl-7-Oxo-Dehydroepiandrosterone for Healing Treatment-Resistant Posttraumatic Stress Disorder in Women: 5 Case Reports

J Clin Psychiatry 2006;67(3):493-496 [letter]

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Sir: Chronic severe posttraumatic stress disorder (PTSD) resulting from early physical and/or sexual abuse is a highly prevalent psychiatric condition in women. PTSD causes persistent functional impairment and emotional distress and generally shows only a limited response to current available psychopharmacologic treatments. Selective serotonin reuptake inhibitors (SSRIs), the most commonly used and only U.S. Food and Drug Administration–approved treatment for this condition, have shown a modest treatment effect of between 0.3 and 0.5.1–3​