The article you requested is

Commentary: Use of Treatment Algorithms for Depression. [CME]

J Clin Psychiatry 2006;67(9):1458-1465

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Dr. Trivedi: The effectiveness of treatment algorithms rests on 3 principles. The 3 broad categories requiring special attention are (1) the determination of the need for sequential treatment algorithms; (2) what should be the placement of various treatment interventions in treatment algorithms with sequenced treatments, e.g., at what point should combination treatments and somatic treatments be included; and finally, (3) what the process or procedure is to implement algorithms in the clinical setting, e.g., the use of recently developed measurement-based care.1

Dr. Osser: It is clear to me that there are significant differences between the likely outcome of people receiving treatment as usual (TAU) as opposed to algorithm-driven treatment.​