Cognitive and Functional Effects of Atypical Antipsychotic Medications
J Clin Psychiatry 2006;67(10):e13
© Copyright 2016 Physicians Postgraduate Press, Inc.
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Several meta-analyses and
some direct comparative studies of atypical antipsychotics indicate that these
medications may be more effective than conventional antipsychotic medications
at enhancing cognition. However, differences in studies exist: short-term
studies of cognitive enhancement may not provide similar results to long-term
studies, while comparative studies are superior to meta-analyses. Direct
measurement of changes in functional capacity may be a desirable study feature,
and the population studied, including the treatment subjects receive, is likely
to have a substantial impact on the results. Additionally, cognitive enhancement
is not a stand-alone phenomenon. Depression and negative symptoms, for example,
also affect an individual with schizophrenia and his or her functioning in the
real world as opposed to within clinical studies.
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