Manic Switch in a Patient With Treatment-Resistant Bipolar Depression Treated With Modafinil
J Clin Psychiatry 2006;67(11):1817 [letter]
© Copyright 2016 Physicians Postgraduate Press, Inc.
Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.
Sir: A number of prospective open-label studies and case reports and 1 placebo-controlled study (showing a significant effect vs. placebo on the Clinical Global Impressions-Improvement scale and positive trends in affective rating scales) suggest that the novel psychostimulant modafinil might be a useful augmentation treatment for depressive patients who are partially responsive or nonresponsive to antidepressants.1–5 This finding applies mainly to the unipolar subtype; however, a few cases of bipolar depression are reported.1–5 No switch into mania to our knowledge has been reported yet with modafinil, in contrast to other antidepressants and psychostimulants.