Commentary: The Failure of Evidence-Based Medicine to Guide Treatment of Antidepressant Nonresponders
J Clin Psychiatry 2006;67(12):1833-1835
© Copyright 2015 Physicians Postgraduate Press, Inc.
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Depression is one of the world’s greatest health
and prompt recognition and vigorous
treatment to remission are the best means to reduce the
global illness burden, increased mortality, and untold suffering
associated with depressive disorders. As I have reviewed
elsewhere, dozens of randomized controlled trials
(RCTs) have documented that antidepressant pharmacotherapy,
the most widely used treatment for depression,
has limited efficacy.2–5