Chronic Leukocytosis Associated With Clozapine: A Case Series

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Sir: The potential for clozapine, a dibenzodiazepine derivative, to cause leukopenia/agranulocytosis is well-known; however, leukocytosis associated with clozapine has been reported infrequently, particularly in the U.S. literature. Persistent clozapine-associated leukocytosis without fever or other complications is rarely reported.1 Leukocytosis, defined as a white blood cell (WBC) count greater than 11,000/mm3 (11 × 109/L), is frequently found in the course of routine laboratory testing.​

J Clin Psychiatry 2007;68(3):484-488 [letter]