Aripiprazole and Worsening of Psychosis: A Case Report

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Sir: Crossman and Lindenmayer1 describe 4 cases of highdose aripiprazole in treatment-refractory schizophrenia, among which 1 showed improvement and all tolerated the drug satisfactorily. As a counterpoint to that report, we report worsening of psychosis, temporally associated with aripiprazole use, and offer our comments on relapse seen on introducing aripiprazole in the presence of other antipsychotics and thus the need for careful cross-titration at any drug dosage. Aripiprazole is a new atypical antipsychotic with partial D2- and 5-HT1A–agonist properties and 5-HT2A–antagonist properties.

J Clin Psychiatry 2007;68(5):805-806