Dosing of Divalproex Extended Release

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Sir: I read with great interest the article by Bowden et al.1 in the October 2006 issue of the Journal. This important study establishes the efficacy and safety of using divalproex sodium extended release (ER), a relatively new formulation of divalproex sodium, for treating acute mania. In that study, divalproex ER was initiated using a dose of 25 mg/kg rounded up to the nearest 500 mg.​

J Clin Psychiatry 2007;68(7):1146-1147