Prolonged QT Associated With an Overdose of Trazodone

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Sir: QT prolongation, torsades de pointes ventricular tachycardia, and sudden death have been associated with a variety of neuropsychiatric medications, particularly neuroleptics and tricyclic antidepressants.1 Case reports have documented QT prolongation after overdose with serotonin reuptake inhibitors.2 Trazodone is an atypical antidepressant that has rarely been associated with QT prolongation in humans,3–5 although an association has been reported in animals.6

J Clin Psychiatry 2007;68(8):1309-1310