Reply to More on Placebo Response

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Sir: We are pleased that our article1 on the placebo response in the escitalopram randomized controlled trials has generated some discussion.

Dr. Mattes’s first point is that there are fewer untreated depressed patients in the community than there used to be. Epidemiologic data certainly indicate that over the past decade or more, there has been an increase in treatment rate in patients with a mental disorder in the United States.2​​

J Clin Psychiatry 2007;68(12):1984-1985