Inconclusive Evidence for the Efficacy of Olanzapine in the Treatment of Negative Symptoms in Schizophrenia

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Sir: In a recent systematic review of the pharmacologic treatment of primary negative symptoms in schizophrenia, my colleagues and I1 concluded that there was a paucity of evidence regarding efficacy of treatments of primary negative symptoms and that the lack of standardized research designs had led to marked inconsistencies in results. A case in point was olanzapine’s efficacy against primary negative symptoms. Of the 4 conducted trials, the only study to use selected patients with primary negative symptoms found no benefit2; 2 studies using path analysis suggested the reverse,3,4 while a third was ambivalent.5

J Clin Psychiatry 2008;69(1):164-164