Co-Occurrence of Binge Eating Disorder With Psychiatric and Medical Disorders
J Clin Psychiatry 2008;69(2):266-273
© Copyright 2015 Physicians Postgraduate Press, Inc.
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Background: Prior studies suggest that certain psychiatric and
medical disorders co-occur with binge eating disorder (BED). However, there has
been no large, community-based study with diagnoses made by clinician
interviewers. We used data from that type of study to assess the co-occurrence
of various psychiatric and medical disorders with DSM-IV BED and with
Method: From October 2002 to July 2004, we interviewed 150
probands with BED, 150 probands without BED, and 888 of their first-degree
relatives (135 of whom had BED, and 54 of whom met specific partial criteria
for BED that we defined as subthreshold BED). Study participants were
interviewed using the Structured Clinical Interview for DSM-IV to assess BED
and other psychiatric disorders and a supplemental structured interview to
assess certain medical disorders; participants also completed a self-report
questionnaire, the Bad Things Scale. For each psychiatric and medical disorder,
we calculated the age- and sex-adjusted co-occurrence odds ratio: the odds of
having that disorder in one's lifetime among individuals with (full or
subthreshold) lifetime BED compared to individuals without lifetime BED. We
also used subjects' responses to the Bad Things Scale to adjust for adversity
over-reporting, a type of response bias that could result in spurious findings
Results: Full BED co-occurred significantly with bipolar
disorder, major depressive disorder, bulimia nervosa but not anorexia nervosa,
most anxiety disorders, substance use disorders, body dysmorphic disorder,
kleptomania, irritable bowel syndrome, and fibromyalgia. These results changed
little after correcting for adversity over-reporting. Subthreshold BED
co-occurred significantly with many, but not all, of the significantly
co-occurring disorders for full BED.
Conclusion: BED and, to a lesser degree, subthreshold BED
exhibit substantial lifetime co-occurrence with psychiatric and medical