Misdiagnosis of Bipolar II Disorder as Major Depressive Disorder
J Clin Psychiatry 2008;69(3):501-502 [letter]
© Copyright 2016 Physicians Postgraduate Press, Inc.
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Table 2 of the recent ACADEMIC HIGHLIGHTS on preventing
recurrent depression in patients with major depressive disorder
reports that, despite maintenance treatment with
antidepressants, recurrences may occur in 6% to 66% of patients
with MDD (vs. 23% to 100% of patients with MDD who
received placebo). This apparent high risk of recurrence in
MDD has been attributed to placebo response, nonadherence, and tachyphylaxis (explained as an emotional blunting due to
selective serotonin reuptake inhibitors, not as a true recurrence).
1 Along with a possible loss of effect of antidepressants
in the long run,2
the problem of the high proportion of bipolar
depression, especially the depression of bipolar II disorder, misdiagnosed
as MDD3–5 is not reported as a possible cause of