High-Dose Olanzapine Versus Clozapine
J Clin Psychiatry 2008;69(10):1660 [letter]
© Copyright 2015 Physicians Postgraduate Press, Inc.
Because this piece has no abstract, we have provided for your benefit the first 3 sentences of the full text.
Sir: The article by Meltzer and colleagues1 suggesting
that high-dose olanzapine may be equivalent to clozapine in
treatment-resistant schizophrenics warrants some discussion.
The authors’ power analysis suggested that 17 patients per
group would be sufficient to provide 80% power. However, the
power analysis (as is often the case) did not consider dropouts,
and this was a particular concern in this study since 6 of 21 patients
receiving clozapine dropped out prior to 6 weeks.