High-Dose Olanzapine Versus Clozapine

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Sir: The article by Meltzer and colleagues1 suggesting that high-dose olanzapine may be equivalent to clozapine in treatment-resistant schizophrenics warrants some discussion.

The authors’ power analysis suggested that 17 patients per group would be sufficient to provide 80% power. However, the power analysis (as is often the case) did not consider dropouts, and this was a particular concern in this study since 6 of 21 patients receiving clozapine dropped out prior to 6 weeks.​

J Clin Psychiatry 2008;69(10):1660