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Correlation ID:c8ef3623-d172-4c17-acd1-a812ac27c741


The article you requested is

High-Dose Olanzapine Versus Clozapine

J Clin Psychiatry 2008;69(10):1660 [letter]

Because this piece has no abstract, we have provided for your benefit the first 3 sentences of the full text.

Sir: The article by Meltzer and colleagues1 suggesting that high-dose olanzapine may be equivalent to clozapine in treatment-resistant schizophrenics warrants some discussion.

The authors’ power analysis suggested that 17 patients per group would be sufficient to provide 80% power. However, the power analysis (as is often the case) did not consider dropouts, and this was a particular concern in this study since 6 of 21 patients receiving clozapine dropped out prior to 6 weeks.​