Drs. Meltzer and Jayathilake Reply

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Sir: Dr. Jeffrey Mattes’s criticism of the power analysis in our study is, in part, well taken, if we did not make it sufficiently clear that dropouts were considered in our original power analysis.

We had calculated that it was necessary to recruit 40 subjects per treatment arm in order to achieve 80% power with an expected 25% dropout rate. However, we were unable to recruit more than 21 and 19 patients in the clozapine and olanzapine arms, respectively.​

J Clin Psychiatry 2008;69(10):1660-1661