Brainstorms: The Sigma Enigma: Can Sigma Receptors Provide a Novel Target for Disorders of Mood and Cognition?
J Clin Psychiatry 2008;69(11):1673-1674
© Copyright 2016 Physicians Postgraduate Press, Inc.
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Sigma receptors are provocative,
mysterious, and controversial
targets of many psychotropic drugs and
are only now beginning to be understood.
Sigma receptors are not a type of
opiate receptor nor a type of receptor
on the NMDA (N-methyl-D-aspartate)
glutamate receptor complex, but they
are now known to be a unique set of
proteins with at least 2 subtypes of receptors:
σ1 and σ2.
Sigma receptors are located in many
tissues where they represent sites in
the endoplasmic reticulum (ER), not in