Lithium and Suicidal Behaviour in Patients With Bipolar Disorder
J Clin Psychiatry 2008;69(11):1831-1932 [letter]
© Copyright 2015 Physicians Postgraduate Press, Inc.
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Sir: We read with great interest the excellent article by
Marangell et al. In this case-control analysis of the impact of
lithium (and other) pharmacotherapy on prospectively observed
suicidal behavior in patients with bipolar disorders, the authors
did not find an association between lithium (and other mood
stabilizer) use and suicide attempts or completed suicides. This
is in contrast with recent meta-analyses showing that in patients
with major mood disorders, long-term lithium treatment
reduces the risk of suicidal behavior by 60% to 90%.