Extreme Creatine Phosphokinase Elevation in a 20-Year-Old Man Participating in a Clinical Trial of Major Depressive Disorder
J Clin Psychiatry 2008;69(11):1832-1834 [letter]
© Copyright 2015 Physicians Postgraduate Press, Inc.
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Sir: Creatine phosphokinase (CPK) is an enzyme primarily
found in cardiac and skeletal muscle as well as in brain tissue
and the gastrointestinal tract. More specifically, CPK is involved
in the conversion of adenosine triphosphate and creatine
to adenosine diphosphate and creatine phosphate via the transfer
of a high-energy phosphate. Minor elevations of CPK occur
routinely with strenuous exercise, hypothyroidism, and statinassociated