Suicidal Ideation and Varenicline: A Possible Case of Mistaken Adverse Drug Reaction?
J Clin Psychiatry 2008;69(11):1834-1835 [letter]
© Copyright 2015 Physicians Postgraduate Press, Inc.
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Sir: Varenicline, an a4ß2 nicotinic acetylcholine partial agonist,
has been licensed in the United Kingdom (and approved in
the United States) for the treatment of tobacco dependence
since 2006. Studies have shown varenicline to result in higher
smoking cessation rates over placebo, bupropion, and nicotine
replacement therapy (NRT). In the one study conducted to
date, varenicline was also seen to be effective in smokers with
mental illness, there being no evidence of excess adverse events
or exacerbation of preexisting conditions.