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Correlation ID:4a93d3e9-19cf-4267-a6c4-154c08564833

A Polymorphism in the Angiotensin-Converting Enzyme Gene Is Associated With Smoking Behaviour

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Sir: Nicotine abuse and dependence is a complex addictive disorder with a pronounced genetic background. In addition, it is one of the strongest risk factors for cardiovascular disorders (CVD). It has been extensively discussed whether the known high comorbidity between CVD and major depressive disorder (MDD) is more likely determined by biological, such as genetic, variables or by behavioral changes caused by depression, which in turn enhance cardiovascular risks. Functional polymorphisms of the angiotensin-converting enzyme (ACE) gene are susceptibility factors for MDD.​

J Clin Psychiatry 2008;69(12):1983-1985