The Spectrum of Psychotic Disorders: Neurobiology, Etiology, and Pathogenesis

View This PDF

NB: This article is only available as a PDF.

Because this piece has no abstract, we have provided for your benefit the first 3 sentences of the full text.

Decades of research into the intrinsic (e.g., neurobiological and genetic) and extrinsic (including in utero and prenatal insults, substance abuse, and traumatic experiences) etiologic factors for psychotic disorders, particularly schizophrenia and related primary illnesses, has contributed greatly toward an improved understanding of the neurobiological underpinnings of their characteristic symptoms and signs. Schizophrenia-like psychotic experiences and behavior, however, are present in a variety of other psychiatric illnesses that are not classified as primary psychotic disorders and in general medication conditions that adversely affect the central nervous system.

In this volume, Drs. Fujii and Ahmed argue for a reconceptualization of schizophrenia-like psychotic phenomena present in primary psychotic and mood disorders, as well as in a variety of other general medical contexts, as a common neurobiological syndrome that involves dysfunction in frontal and temporal systems and/or disturbances in their functional connectivity.​

J Clin Psychiatry 2008;69(12):1987-1988