ASCP Corner: All Antipsychotics Are Equal, but Some Are More Equal Than Others
J Clin Psychiatry 2009;70(3):429-430
© Copyright 2014 Physicians Postgraduate Press, Inc.
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One of the “atypical” features of second-generation antipsychotics
(SGAs) that was quickly appreciated by clinicians
and patients shortly after their introduction was that these
medications were shown to elicit fewer extrapyramidal side
effects than the first-generation antipsychotics (FGAs). Early
head-to-head comparisons of some first-line SGAs with FGAs
in patients with schizophrenia also demonstrated better efficacy
in terms of overall symptom reduction in studies comparing
risperidone and olanzapine with haloperidol. However, later
studies failed to demonstrate the superiority of SGAs over
FGAs in effectiveness or safety.