Reply to Augmentation of Dopaminergic Agents for Major Depressive Disorder
J Clin Psychiatry 2009;70(3):433-434 [letter]
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Letter to the Editor
Sir: Thank you for offering us the opportunity to respond to
the letter from Pae et al. that addresses our recent publication in
First, we would like to reiterate that the number of subjects
was based on a power analysis, using the available data on expected
change between groups and established a priori. While it
is possible that if sample sizes were significantly increased the
smaller differences might become statistically significant, this
may not necessarily be of clinical significance or value.