Folate Supplementation: Is It Safe and Effective?
J Clin Psychiatry 2009;70(5):767 [letter]
© Copyright 2015 Physicians Postgraduate Press, Inc.
Letter to the Editor
Sir: In the September 2008 issue of the Journal, Stahl reviews
L-methylfolate as a possibly helpful adjunctive antidepressant
agent,1 and Mischoulon and Fava briefly review the
evidence that folates, including folic acid, a stable synthetic
substance, could be useful augmenting antidepressant agents.
However, there is some evidence of possibly harmful or, at the
least, disappointing effects of folate supplementation.
- There has long been a concern that folate supplementation
might mask, or even worsen, the manifestations
of B12-deficiency anemia. L-Methylfolate may be less
likely to do this than folic acid.