Folate Supplementation: Is It Safe and Effective?

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Letter to the Editor

Sir: In the September 2008 issue of the Journal, Stahl reviews L-methylfolate as a possibly helpful adjunctive antidepressant agent,1 and Mischoulon and Fava briefly review the evidence that folates, including folic acid, a stable synthetic substance, could be useful augmenting antidepressant agents. However, there is some evidence of possibly harmful or, at the least, disappointing effects of folate supplementation.

  1. There has long been a concern that folate supplementation might mask, or even worsen, the manifestations of B12-deficiency anemia. L-Methylfolate may be less likely to do this than folic acid.

J Clin Psychiatry 2009;70(5):767