Aripiprazole Treatment of Risperidone-Induced Hyperprolactinemia

Jing Xu Chen, Yun Ai Su, Shao Li Wang, Qing Tao Bian, Yan Hong Liu, Ning Wang, Fu De Yang, Colin Haile, Thomas R. Kosten, and Xiang Yang Zhang

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Letter to the Editor

Sir: Hyperprolactinemia is a well-recognized complication of some antipsychotic agents that results from the blocking of dopamine-2 (D2) receptors in the anterior pituitary. Aripiprazole, a potent partial agonist of the D2 receptors, inhibits spontaneous prolactin release from isolated anterior pituitary slices. Clinically, switching to aripiprazole monotherapy resolves antipsychoticinduced hyperprolactinemia.

J Clin Psychiatry 2009;70(7):1058-1059

https://doi.org/10.4088/JCP.08l04671

© Copyright 2009 Physicians Postgraduate Press, Inc.