Aripiprazole Treatment of Risperidone-Induced Hyperprolactinemia

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Letter to the Editor

Sir: Hyperprolactinemia is a well-recognized complication of some antipsychotic agents that results from the blocking of dopamine-2 (D2) receptors in the anterior pituitary. Aripiprazole, a potent partial agonist of the D2 receptors, inhibits spontaneous prolactin release from isolated anterior pituitary slices. Clinically, switching to aripiprazole monotherapy resolves antipsychoticinduced hyperprolactinemia.

J Clin Psychiatry 2009;70(7):1058-1059