Can Pindolol Really Enhance Antidepressant Effect?
J Clin Psychiatry 2011;72(11):1558 [letter]
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Letter to the Editor
Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.
To the Editor: In their recent article, Portella and colleagues1 claim that pindolol can accelerate and enhance antidepressant effect of selective serotonin reuptake inhibitors (SSRIs). As one of the authors of another recent meta-analysis of pindolol augmentation,2 I would like to comment on their results.
From their meta-analysis,1 the number needed to treat (NNT) was calculated as 6 for early clinical response (ie, acceleration of antidepressant effect at 10 days to 2 weeks) and as 13 for late clinical response (ie, enhancement of antidepressant effect at 4 to 6 weeks).