The article you requested is
Strategies for Achieving Full Remission When First-Line Antidepressants Are Not Enough
J Clin Psychiatry 2013;74(12):e26
© Copyright 2015 Physicians Postgraduate Press, Inc.
Access to this article is available to valid users
Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send email
Register: If you do not have one already, register for a free account.
Remission rates for patients with major depressive disorder are discouragingly low. Even when first-line treatment is administered at an adequate dose for a sufficient duration, approximately two-thirds of patients will fail to achieve remission, and many who remit have residual symptoms. Clinicians must assess problems with the first treatment and select the most appropriate second-line treatment based on patient preference, clinical judgment, and any comorbid conditions. Strategies like implementing psychotherapy, switching agents, or augmenting antidepressants may help patients achieve remission. Patients may also require adjunctive therapy to target common residual symptoms such as fatigue or insomnia.
See the entire activity.