Adjuvant Therapeutic Effects of Galantamine on Apathy in a Schizophrenia Patient

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Sir: The limitations of the current medications used to treat schizophrenia have led to a search for adjunctive treatments that may better address the negative symptoms, cognitive deficits, and behavioral problems of the disorder. A promising strategy might be adopted from the current use of acetylcholinesterase inhibitors in the treatment of Alzheimer’s disease.1 Acetylcholinesterase inhibitors (e.g., tacrine, donepezil) improve general cognitive functioning and reduce apathy, anxiety, agitation, and other psychiatric symptoms in Alzheimer’s patients. Galantamine has a dual mechanism of action that may offer particular benefits for individuals with schizophrenia.

J Clin Psychiatry 2004;65(12):1723-1724