Blue Genes and the Monoamine Hypothesis of Depression

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Although the monoamine hypothesis of depression proposes that depression is due to a deficiency in monoaminergic neurotransmission, no deficiencies in the levels or receptors for serotonin, dopamine, and/or norepinephrine have been consistently reported. Currently, the evolving monoamine hypothesis considers the possibility that depression may be linked to a deficiency in signal transduction from the monoamine neurotransmitter to its postsynaptic neuron in the presence of normal amounts of neurotransmitter and receptor. Such a deficiency in the molecular events that cascade from receptor occupancy by neurotransmitter to transcription of genes could lead to a deficient response of target neurons to neurotransmission and thus, depression.

J Clin Psychiatry 2000;61(2):77-78