Two Cases of Acneiform Eruption Associated With Lamotrigine

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Sir: Lamotrigine (3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4- triazine) is an anticonvulsant commonly used for the treatment of epilepsy. More recently, it has also become widely used in psychiatry for the treatment of bipolar disorder.1 It is generally well tolerated. Benign skin reactions such as morbilliform, urticarial, or maculopapular rash occur in approximately 10% of patients.2

J Clin Psychiatry 2004;65(12):1720-1722