A Cautionary Note When Using Zonisamide in Youths: A Case Report of Association With Toxic Epidermal Necrolysis

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Sir: Zonisamide is a third-generation sulfonamide anticonvulsant indicated for treatment of partial seizures. As with other anticonvulsants, it has shown efficacy in treating bipolar disorder in adults1 and, unlike other agents, does not appear to cause weight gain. Zonisamide is contraindicated in patients with known sulfa allergies due to the risk of developing a medically serious rash.

J Clin Psychiatry 2004;65(12):1720-1720