Fulminant Hepatic Failure From Acetaminophen in an Anorexic Patient Treated With Carbamazepine

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Sir: We report a case in which a low overdose of acetaminophen resulted in hepatic failure requiring liver transplantation. We hypothesize that the severity of this patient’s reaction was caused by the effects of an ongoing eating disorder in combination with the use of carbamazepine for treatment of a mood disorder, acting in a synergistic manner to magnify the toxic effects of acetaminophen. The association between eating disorders, carbamazepine, and acetaminophen overdose is discussed, an association that highlights the importance of evaluating disordered behaviors, as well as coadministered medications, in order to predict the severity of response to acetaminophen overdose.

J Clin Psychiatry 1998;59(11):622