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For a first-episode patient with predominantly positive symptoms, the experts consider oral risperidone the treatment of choice. Other recommended medications for this clinical situation are aripiprazole, olanzapine, ziprasidone, and quetiapine (although the first two were rated first line and the second two high second line, these options clustered together and all were rated first line by approximately two-thirds of the experts).

For a first-episode patient with predominantly negative symptoms, the experts recommend one of the newer oral atypical antipsychotics.

J Clin Psychiatry 2003;64(suppl 12):21-51