Is Statin Use Safe in Individuals With Psychotic Disorders?

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Sir: Individuals with schizophrenia and other serious mental illnesses have a mortality rate at least 2 times as high as those without psychotic disorders, with the excess mortality largely attributed to higher rates of death from cardiovascular disease.

Wider use of cholesterol-lowering drugs (statins) to reduce cardiovascular risk in this setting has been suggested. However, widespread use of statin drugs in individuals with psychotic disorders may raise some concerns.

J Clin Psychiatry 2008;69(9):1499-1499