Reply to Augmentation of Dopaminergic Agents for Major Depressive Disorder

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Letter to the Editor

Sir: Thank you for offering us the opportunity to respond to the letter from Pae et al. that addresses our recent publication in the Journal.

First, we would like to reiterate that the number of subjects was based on a power analysis, using the available data on expected change between groups and established a priori. While it is possible that if sample sizes were significantly increased the smaller differences might become statistically significant, this may not necessarily be of clinical significance or value.

J Clin Psychiatry 2009;70(3):433-434