Sponsored Clinical Trials and Bias

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Sir: I read with great interest your editorial1 and the 2 letters from the February 2007 issue of your journal2,3 highlighting the important concern about the source of funding influence on the outcome of interest.

In addition to the recent review by Heres et al.4 that you refer to in your editorial,1 the relationship between funding source and study outcome, which is so beautifully illustrated by the exchange between your 2 correspondents,2,3 was investigated in several other published studies.5–15 With one exception,11 these studies showed that industry support was uniformly associated with positive study outcome for the sponsored intervention either as a trend8 or, most times, at significant levels.5,6,9,10,12–15

J Clin Psychiatry 2007;68(10):1621-1622