The Use of Alosetron to Treat SSRI-Induced Gastrointestinal Symptoms

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Sir: The use of selective serotonin reuptake inhibitors (SSRIs) across a wide range of psychiatric disorders is well documented in the literature.1 The SSRIs are generally well tolerated and dosed once daily, features that enhance compliance.2 However, among the common side effects of SSRIs are gastrointestinal reactions including nausea, diarrhea, loose stools, and constipation.3

Primary Care Companion J Clin Psychiatry 2000;2(4):143 [letter]