Panic Attacks During Escalation of Mirtazapine

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Sir: Mirtazapine is a unique antidepressant that involves both serotonergic and noradrenergic enhancement through blockade of the α2 -autoreceptor and α2 -heteroreceptor.1 It is also a 5-HT2 blocker, which makes it a potential anxiolytic agent.2 Overall, mirtazapine appears to be a useful agent in patients with depression coexisting with anxiety symptoms.3​​

Primary Care Companion J Clin Psychiatry 2003;5(2):93-93 [letter]