Aripiprazole Worsens Psychosis: A Case Report

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Sir: Aripiprazole is a second-generation antipsychotic medication with a unique mechanism of action. It acts as a functional antagonist or functional agonist at dopamine and serotonin receptors, depending upon the level of the relevant neurotransmitter in the immediate environment, and for this reason, it is known as a dopamine-serotonin system stabilizer.1 Due to the partial-agonist D2 receptor activity of aripiprazole, it has been suggested to worsen psychosis.2 We report a case in which the unique mechanism of action of aripiprazole probably contributed to relapse of psychotic symptoms.​

Prim Care Companion J Clin Psychiatry 2006;8(6):380-381 [letter]