Aripiprazole Worsens Psychosis: A Case Report
Prim Care Companion J Clin Psychiatry 2006;8(6):380-381 [letter]
© Copyright 2017 Physicians Postgraduate Press, Inc.
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Sir: Aripiprazole is a second-generation antipsychotic medication
with a unique mechanism of action. It acts as a functional
antagonist or functional agonist at dopamine and serotonin receptors,
depending upon the level of the relevant neurotransmitter
in the immediate environment, and for this reason, it is
known as a dopamine-serotonin system stabilizer.1 Due to the
partial-agonist D2 receptor activity of aripiprazole, it has been
suggested to worsen psychosis.2
We report a case in which the unique mechanism of action
of aripiprazole probably contributed to relapse of psychotic