Quetiapine-Induced Hypersalivation

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Sir: Quetiapine fumarate is a dibenzothiazepinederivative antipsychotic with combined antagonism at dopamine (D1, D2) and serotonin type 1 and type 2 (5-HT1A, 5-HT2A, 5-HT2C) receptors. Additionally, quetiapine antagonizes α1- and α2-adrenergic and histamine H1 receptors. Protean binding at the above receptors explains the common side effects, which include hypersomnolence, hypotension, headache, weight gain, and gastrointestinal disturbance.​

Prim Care Companion J Clin Psychiatry 2007;9(3):233 [letter]