Chlorpromazine-Induced Skin Pigmentation With Short-Term Use in a Patient With Bipolar Disorder: A Case Report

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Sir: Chlorpromazine is known, in rare instances, to induce skin pigmentation in areas exposed to sunlight.1 The prevalence in chronic, hospitalized patients is reported as 1.0% to 2.9%.2 Some authors report chlorpromazine-induced skin pigmentation as irreversible,3 while some findings4 indicate that it is completely reversible and that a variety of neuroleptics, including other phenothiazines, are used to replace chlorpromazine without risk of reemergence of pigmentation.4

Prim Care Companion J Clin Psychiatry 2007;9(4):316-317 [letter]